Noam A. Cohen

Evaluating Spike Antigenicity across Endemic Human Coronavirus Models using Flow Virometry

This study uses flow virometry to analyze spike antigenicity of endemic human coronaviruses, revealing cell line-dependent differences and heterogeneity not captured by bulk assays.

Pseudomonas aeruginosa metabolite 3-oxo-C12HSL induces apoptosis through T2R14 and the mitochondrial calcium uniporter

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response

This study compares how SARS-CoV-2 and MERS-CoV nsp1 proteins affect host protein synthesis and the integrated stress response, revealing differential impacts on eIF2 phosphorylation and stress granule formation.

Clade C MERS-CoV camel strains vary in protease utilizationduring viral entry

This study compares protease utilization in Clade C MERS-CoV camel strains, finding reduced TMPRSS2-mediated entry in East African isolates compared to Clade A/B strains.

Human olfactory organoids as an in vitro model of the olfactory epithelium

This study generates human olfactory organoids that exhibit immunostaining, gene expression, and odorant-induced Ca2+ mobilization, mimicking olfactory epithelium function.

Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes

The paper presents a pipeline using PacBio CCS to sequence full-length 16S rRNA genes for species-level microbiome analysis, showing high accuracy in mock communities and variation in sinonasal microbiomes.

Tissue dependent expression of bitter receptor TAS2R38 mRNA

The paper investigates whether TAS2R38 mRNA expression in taste tissue correlates with expression in sinonasal tissue among heterozygotes, finding no significant relationship.

Cytokine profile in human olfactory cleft mucus and associated changes in olfactory function

The paper investigates age-related olfactory loss by analyzing cytokine levels in human olfactory mucus and their association with olfactory function decline.