Anders Brunse

Ketone and glycolytic metabolism are key modulators of inflammation during neonatal sepsis

This study shows that inhibiting glycolysis or supplementing ketones can reduce inflammation and improve outcomes in neonatal sepsis by enhancing mitochondrial metabolism and disease tolerance.

Characterization of a virulent bacteriophage consortium targeting Enterobacteriaceae from inflamed preterm gut mucosa

This study isolates and characterizes virulent bacteriophages targeting Enterobacteriaceae from preterm piglets with NEC-like inflammation, showing their potential for phage therapy.

Harnessing systemic glycolysis-TCA cycle axis to boost the host defense against newborn infection

The paper shows that boosting TCA cycle activity through nutritional strategies improves neonatal host defense against infection by enhancing disease tolerance and resistance.

Protection against necrotizing enterocolitis by fecal filtrate transfer requires an active donor virome

This study shows that active donor virome in fecal filtrate transfer reduces NEC severity in preterm piglets, while inactivated virome abolishes these protective effects.

Reduced glucose supply during neonatal infection attenuates neurological and renal pathology via modulation of innate and Th1 immunity

This study shows that reducing glucose supply in infected preterm pigs decreases neurological and renal damage by modulating innate and Th1 immunity.

Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation

This study shows that chemostat culturing reduces eukaryotic virus load in fecal viromes and delays diarrhea in preterm piglets, but does not prevent NEC and reduces microbiome effects.