Klaus Bønnelykke

Sex-different phenotypic correlations: Due to genes or environment?

The paper identifies sex-different phenotypic correlations in the UK Biobank and decomposes them into genetic and environmental contributions, finding environmental factors dominate.

Reduced parenteral glucose supply in preterm neonatal infection ameliorates the pulmonary damage

This study shows that reducing glucose supply in preterm infants with infection reduces pulmonary damage and metabolic disturbances.

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

Harnessing systemic glycolysis-TCA cycle axis to boost the host defense against newborn infection

The paper shows that boosting TCA cycle activity through nutritional strategies improves neonatal host defense against infection by enhancing disease tolerance and resistance.

Network medicine-based epistasis detection in complex diseases: ready for quantum computing

The paper introduces NeEDL, a network medicine-based method for detecting higher-order epistatic interactions in complex diseases, showing improved statistical significance and applicability across eight diseases.

Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

Nasal DNA methylation at three CpG sites predicts childhood allergic disease

The paper identifies three nasal DNA methylation CpG sites that predict childhood allergic disease with high accuracy, validated across Dutch and US Hispanic children.

Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And Craniosynostosis

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

Kernel integration by Graphical LASSO

The paper introduces a method for integrating heterogeneous biological data using a graphical LASSO framework and applies it to study asthma and eczema risk factors in children.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.

Consortium genome-wide meta-analysis for childhood dental caries traits

This paper conducts a consortium-wide GWAS to identify genetic variants associated with childhood dental caries, finding two significant loci but low heritability estimates.

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.