Author

Nathan Suek

Columbia University Irving Medical CenterORCID 0000-0002-0253-8950Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Farshid FathiiD· 2 shared Megan SykesiD· 2 shared Adam D. GriesemeriD· 1 shared Andrew Kelvin SewelliD· 1 shared Anoma NelloreiD· 1 shared Aprajita MattooiD· 1 shared Audrey V. ParentiD· 1 shared Austin CheniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Farshid FathiORCID

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2 papers

Recent·Most cited

Coordinated circulating and tissue-based T cell responses precede xenograft rejection

Ekaterina V. Novikova, Elizabeth Severa, Han Chen, Elizabeth Doepke, Fiorella Chacon, Farshid Fathi, Nathan Suek, Benjamin Vermette, Robin G Bombardi, Eloi Schmauch, Simon Hedley Williams, Jacqueline I. Kim, Imad Aljabban, Tal Eitan, Ian S. Jaffe, , Ramin S. Herati

This study tracks T cell clonotypes across tissues in a pig-to-human kidney xenotransplantation model, showing coordinated immune responses preceding xenograft rejection.

The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

Giorgia Zanetti, Mateusz Legut, Austin Chen, Farshid Fathi, Nathan Suek, Nato Teteloshvili, Hao Wei Li, Xiaolan Ding, Daniel Traum, Klaus H. Kaestner, Ryan E. Hoang, Edwin Bremer, Andrew Kelvin Sewell, Audrey V. Parent, Rémi J. Creusot, , Mohsen Khosravi Maharlooei

This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.

bioRxiv · Feb 20, 2026 · PreprintImmunology