Mian Cao

Dysregulation of miR-103a-3p/AGFG1 axis links endocytic trafficking dysfunction to ER stress in Parkinson's disease

This study identifies the miR-103a-3p/AGFG1 axis as a molecular link between endocytic trafficking dysfunction and ER stress in Parkinson's disease, with AGFG1 as a potential therapeutic target.

Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms

Focal dopaminergic axon swellings in the dorsolateral striatum of Synj1 R259Q mutant mice are clusters of DAT-rich, onion-like plasma membrane invaginations, and the same region shows reduced evoked dopamine release.

An EEG-based Multi-Scale Hybrid Attention and Squeeze Network for objective taste assessment

This paper introduces MHASNet, a deep learning model for taste assessment using EEG signals, achieving high accuracy across five taste categories.

Synaptic endocytic failure drives dopamine deficiency and protein transfer-mediated striatal dopamine-like neuron compensation

The paper shows that synaptic endocytic failure in dopamine neurons leads to the emergence of dopamine-like neurons through protein transfer, supporting dopamine compensation in early Parkinson's disease.

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

This study shows that mutations in synaptojanin1 and auxilin synergistically worsen dopaminergic axonal pathology in mice, suggesting a role in Parkinson's disease pathogenesis.

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1

The paper shows that combining a Parkinson's disease mutation in synaptojanin 1 with Sac2 knockout in mice leads to severe neurological defects, suggesting Sac2 as a PD risk gene.