Thomas G. Fazzio

This study investigates the roles of esBAF and INO80C in shaping 3D genome organization in mouse embryonic stem cells, finding they influence subcompartment identity and enhancer-promoter interactions.

This study shows that R-loops maintain promoter architecture and balanced lineage allocation during differentiation by influencing H2A.Z occupancy and chromatin structure in mouse embryonic stem cells.

The paper discovers that differentiating murine ES cells communicate over millimeters to form a macroscopic entity that survives if its population density exceeds a threshold.

The paper reanalyzes sperm chromatin structure in mice, finding that prior studies were contaminated by cell-free chromatin, and identifies open loci associated with early development.

This study identifies TAF4b-regulated transcription networks in mouse oocytes, revealing its role in meiosis, chromatin structure, and X-linked gene expression.

The paper introduces multi-CUT&Tag, a method to simultaneously map multiple chromatin proteins in single cells, revealing co-localization and cell-type-specific chromatin features.

The paper develops a method to profile TF-DNA interactions in single cells and embryos, showing NANOG's greater reliance on BRG1 in vivo.

The paper demonstrates that NmeCas9, a Cas9 ortholog, exhibits high-fidelity genome editing in human cells with minimal off-target effects and multiple PAM compatibility.