Author

Colin C. Kovacs

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Doron BeteliD· 4 shared Louise LeyreiD· 4 shared Paul ZumboiD· 4 shared Alberto M. HerreraiD· 3 shared Jared WeileriD· 3 shared Noemi LindeniD· 3 shared Tan Thinh HuynhiD· 3 shared Ali DaneshiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

Doron BetelORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones

Isabella A. T. M. Ferreira, Alberto Herrera, Tan Thinh Huynh, Nathan L. Board, Emily Stone, Noemi Linden, Yanqin Ren, Cíntia Bittar, Virender Kumar Pal, Shane Vedova, Ethan Naing, Parul Sinha, Ali Danesh, Cristian Ovies, Fitty L Liu, , Richard Brad Jones

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

bioRxiv · Feb 23, 2026 · PreprintImmunology

HIV Nef amplifies mechanical heterogeneity to promote immune evasion

Louise Leyre, Farah Mustapha, Alberto M. Herrera, Esther Lee, Emily M. Huntsman, Paul Zumbo, Jared Weiler, Parul Sinha, Ethan Naing, Connor Smith, Colin C. Kovacs, Michael Galiano, Nada Wahman, Doron Betel, Kiera Clayton, , Richard Brad Jones

This study shows HIV Nef induces a soft phenotype in infected CD4+ T cells, reducing their susceptibility to cytotoxic T lymphocyte killing through cytoskeletal remodeling and intrinsic heterogeneity.

bioRxiv · Dec 26, 2025 · PreprintImmunology

The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8+ T-cell revitalization

Andrea Gramatica, Itzayana G. Miller, Adam R. Ward, Khan Farzana, Tyler J. Kemmer, Jared Weiler, Tan Thinh Huynh, Paul Zumbo, Andrew P. Kurland, Louise Leyre, Yanqin Ren, Thaís Klevorn, Dennis C. Copertino, Uchenna K. Chukwukere, Callie Levinger, , R. Brad Jones

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

Cell Reports · May 1, 2025Peer-reviewedImmunology

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells

Alberto M. Herrera, Louise Leyre, Jared Weiler, Noemi Linden, Tan Thinh Huynh, Feng Wang, Colin C. Kovacs, Marina F. Caskey, Paul Zumbo, Maider Astorkia, Sandra N. Terry, Ya‐Chi Ho, Doron Betel, R. Brad Jones

bioRxiv · Dec 22, 2024 · PreprintImmunology