Author

Sandra López-Calcerrada

Research Institute Hospital 12 de OctubreORCID 0000-0002-0385-8067Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Cristina UgaldeiD· 2 shared Agnieszka Rybak‐WolfiD· 1 shared Alessandro PrigioneiD· 1 shared Amin PolziniD· 1 shared ANDREW P. GARNHAMiD· 1 shared Annett BöddrichiD· 1 shared Barbara MlodyiD· 1 shared Carmen MenachoiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Cristina UgaldeORCID

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2 papers

Recent·Most cited

Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in humans

Javier Botella, Enrico Perri, Nikeisha J. Caruana, Sandra López-Calcerrada, Michele Brischigliaro, Nicholas A. Jamnick, Viola M. J. Oorschot, Nicholas J. Saner, Javier Díaz‐Lara, Dale F. Taylor, ANDREW P. GARNHAM, Erika Fernández‐Vizarra, Cristina Ugalde, Georg Ramm, David A. Stroud, , David John Bishop

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

bioRxiv · Dec 19, 2024 · PreprintMolecular Biology

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

Paweł Lisowski, Selene Lickfett, Agnieszka Rybak‐Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, , Alessandro Prigione

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

Nature Communications · Aug 22, 2024Peer-reviewedNeuroscience