Author

Hiroshi Uji‐i

Hokkaido UniversityORCID 0000-0002-0463-9659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Beatrice FortuniiD· 3 shared Indra Van ZundertiD· 3 shared Sandra KrzyzowskaiD· 3 shared Susana RochaiD· 3 shared Farsai TaemaitreeiD· 2 shared Johan HofkensiD· 2 shared María Loreto BravoiD· 2 shared Chentao WeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Beatrice FortuniORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

When lysosomes persist: resolving the proton-sponge paradox in nanoparticle-based intracellular delivery

Indra Van Zundert, Steven Huysecom, Thibo Iven, Sandra Krzyzowska, Vince Goyvaerts, Volker Leen, Johan Hofkens, Hiroshi Uji‐i, Beatrice Fortuni, Susana Rocha

This study investigates how proton-sponge polymers like PEI enable cargo release without full nanoparticle escape, resolving a long-standing debate in nanomedicine.

bioRxiv · May 7, 2026 · PreprintCell Biology

Cellular Responses to Photothermal Therapy: Heat-Induced ERK Signaling and Intercellular Communication in Solid Tumors

Farsai Taemaitree, Yuta Takano, Daisuke Yamaguchi, Kazushi Yamaguchi, Yudai Yamashita, Motosuke Tsutsumi, Chentao Wen, Kohei Otomo, Kenji Hirai, James Andell Hutchison, Indra Van Zundert, Sandra Krzyzowska, Maria Bravo, Sayuki Hirano, Koutarou D. Kimura, , Hiroshi Uji‐i

This study examines how photothermal therapy affects ERK signaling and intercellular communication in tumor spheroids using FRET sensors and deep learning.

bioRxiv · Feb 27, 2025 · PreprintCancer Biology

Nanoparticle Accumulation and Penetration in 3D Tumor Models: the Effect of Size, Shape, and Surface Charge

Pierre Cybulski, María Loreto Bravo, Jim Jui‐Kai Chen, Indra Van Zundert, Sandra Krzyzowska, Farsai Taemaitree, Hiroshi Uji‐i, Johan Hofkens, Susana Rocha, Beatrice Fortuni

This study evaluates how nanoparticle size, shape, and surface charge affect their accumulation and penetration in 2D and 3D tumor models, finding that larger, negatively charged, and spherical NPs perform best.

Frontiers in Cell and Developmental Biology · Jan 24, 2025Peer-reviewedCancer Biology