The paper integrates COFRADIC and sel-TRAP data to refine Nat substrate specificities and uncover cryptic Nt-acetylome substrates from alternative translation initiation.

bioRxiv · Mar 11, 2026 · PreprintGenomics

Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import.

Salomé Nashed, Houssam El Barbry, Médine Benchouaia, Angélie Dijoux-Maréchal, Thierry Delaveau, Nadia Ruiz-Gutierrez, Lucie Gaulier, Déborah Tribouillard‐Tanvier, Guillaume Chevreux, Stéphane Le Crom, Benoı̂t Palancade, Frédéric Devaux, Élodie Laine, Mathilde Garcia

The paper identifies N-terminal signatures in yeast proteins that influence mitochondrial import, showing hydrophobic residues at position 2 are critical and conserved across Saccharomycotina yeasts.

PLoS Genetics · Aug 16, 2023Peer-reviewedGenomics

Eoulsan 2: an efficient workflow manager for reproducible bulk, long-read and single-cell transcriptomics analyses

Nathalie Lehmann, Sandrine Perrin, Claire Wallon, Xavier Bauquet, Vivien Deshaies, Cyril Firmo, Runxin Du, Charlotte Berthelier, Céline Hernandez, Cédric Michaud, Denis Thieffry, Stéphane Le Crom, Morgane Thomas‐Chollier, Laurent Jourdren

Eoulsan 2 updates a workflow manager to support bulk, long-read, and single-cell transcriptomics analyses with improved infrastructure and module development.

bioRxiv · Oct 13, 2021 · PreprintBioinformatics

Local translation in perisynaptic astrocytic processes is specific and regulated by fear conditioning

Noémie Mazaré, Marc Oudart, Julien Moulard, Giselle T. Y. Cheung, Romain Tortuyaux, Philippe Mailly, David Mazaud, Alexis‐Pierre Bemelmans, Anne-Cécile Boulay, Corinne Blugeon, Laurent Jourdren, Stéphane Le Crom, Nathalie Rouach, Martine Cohen‐Salmon

The paper identifies a unique molecular repertoire in hippocampal perisynaptic astrocytic processes, regulated by local translation during fear conditioning.

Cell Reports · Aug 1, 2020Peer-reviewedNeuroscience

Cyclin G And The Polycomb Repressive Complexes PRC1 And PR-DUB Cooperate For Developmental Stability

Delphine Dardalhon-Cuménal, Jérôme Deraze, Camille Dupont, Valérie Ribeiro, Anne Costes, Juliette Pouch, Stéphane Le Crom, Hélène Thomassin, Vincent Debat, Neel B. Randsholt, Frédérique Peronnet

The paper shows Cyclin G interacts with PRC1 and PR-DUB to maintain developmental stability in Drosophila by regulating gene expression related to translation and energy production.

PLoS Genetics · Jul 11, 2018Peer-reviewedDevelopmental Biology

A de novo approach to disentangle partner identity and function in holobiont systems

Arnaud Meng, Camille Marchet, Erwan Corre, Pierre Peterlongo, Adriana Alberti, Corinne Da Silva, Patrick Wincker, Éric Pelletier, Ian Probert, Johan Decelle, Stéphane Le Crom, Fabrice Not, Lucie Bittner

The paper introduces a method to separate host and symbiont reads in holobiont transcriptomes, improving assembly quality and enabling functional analysis.

Microbiome · Jun 9, 2018Peer-reviewedGenomics

Analysis Of The Genomic Basis Of Functional Diversity In Dinoflagellates Using A Transcriptome-Based Sequence Similarity Network

Arnaud Meng, Erwan Corre, Ian Probert, Andres Gutiérrez‐Rodríguez, Raffaele Siano, Anita Annamalé, Adriana Alberti, Corinne Da Silva, Patrick Wincker, Stéphane Le Crom, Fabrice Not, Lucie Bittner

The paper uses a sequence similarity network to analyze dinoflagellate transcriptomes, identifying novel protein domains linked to toxicity and symbiosis.

Molecular Ecology · Apr 6, 2018Peer-reviewedGenomics