Seth A. Sharp

PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic Islets

The paper integrates multiple scRNA-seq datasets to create a comprehensive atlas of human pancreatic islets, identifying 13 cell populations and providing a resource for diabetes research.

Heterogeneous endocrine cell composition defines human islet functional phenotypes

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

DRB1 Subtyping Reveals Divergent Risk and Protection for Type 1 Diabetes in Middle Eastern Populations

The paper develops a machine learning-based T1D risk model tailored to Middle Eastern populations, showing improved performance over existing models in this region.

HumanIslets: An integrated platform for human islet data access and analysis

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

Estimating population level disease prevalence using genetic risk scores

This paper estimates disease prevalence using genetic risk scores and evaluates methods for robust prevalence estimation across different scenarios.

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

This study identifies 47 genetic associations with sleep traits using accelerometer data from 85,670 individuals, including novel variants for sleep quality and duration.

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

This study identifies 351 new genetic loci associated with chronotype using data from 697,828 individuals and links them to circadian biology and disease.

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

A common FGF21 allele is associated with lower body fat in the lower body, higher blood pressure, and increased carbohydrate intake in a large human cohort.