Javier Vitórica

Galectin-3 drives tau-associated neuroinflammation, white matter degeneration and proteomic dysregulation

This study shows that Galectin-3 promotes tau pathology, neuroinflammation, white matter degeneration, and proteomic dysregulation, and that its deletion reduces these effects.

Galectin-3 drives neuroinflammatory amyloid remodeling by stabilizing intermediate Aβ species and altering lysosomal processing

This paper identifies Galectin-3 as a key regulator of amyloid-beta aggregation and microglial dysfunction in Alzheimer's disease, showing its role in neurotoxicity and potential as a therapeutic target.

The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer's disease progression

This study identifies the PHD3-FOXO3 axis as a regulator of the interferon type I response in microglia, which contributes to Alzheimer's disease progression.

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

This study shows that inactivating steroid sulfatase in C. elegans extends lifespan and reduces age-related diseases, suggesting potential therapeutic applications for aging.

Galectin-3, A Novel Endogenous Trem2 Ligand, Regulates Inflammatory Response and Aβ Fibrilation in Alzheimer’s Disease

This study identifies galectin-3 as a novel endogenous TREM2 ligand that regulates microglial activation and Aβ fibrillation in Alzheimer’s disease.