Tim Stearns

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1

This study identifies ALMS1 as an intrinsically disordered protein that mediates cartwheel dynamics during centriole biogenesis, showing its role in forming and disassembling cartwheel seeds and enabling adaptable centriole formation.

Molecular architecture of the ciliary base in mammalian multiciliated cells

This study provides a molecular and structural map of the ciliary base in mammalian multiciliated cells using advanced imaging and molecular techniques.

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages

This study identifies C2CD3 as a radial organizer of the distal centriole and appendages, revealing its role in structuring the luminal ring and interacting with the DISCO complex.

Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi

The paper studies centriole and microtubule cytoskeleton remodeling in chytrid fungi during their lifecycle using bioinformatics, RNA sequencing, and expansion microscopy.

A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

This study identifies a protein complex involving delta-tubulin, epsilon-tubulin, and TEDC1/2 that is essential for centriole architecture and function.

CRISPR/Cas9 Treatment Causes Extended TP53-Dependent Cell Cycle Arrest In Human Cells

This study shows CRISPR/Cas9 treatment causes prolonged cell cycle arrest in human cells dependent on TP53 function and Cas9 DNA binding.