Caitlyn L McCafferty

Stoic: Fast and accurate protein stoichiometry prediction

Stoic predicts protein complex stoichiometry using protein language model embeddings and graph neural networks, achieving fast and accurate results for homomeric and heteromeric complexes.

Molecular architecture of the ciliary base in mammalian multiciliated cells

This study provides a molecular and structural map of the ciliary base in mammalian multiciliated cells using advanced imaging and molecular techniques.

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages

This study identifies C2CD3 as a radial organizer of the distal centriole and appendages, revealing its role in structuring the luminal ring and interacting with the DISCO complex.

The CAGE complex: a hollow, megadalton, protein assembly in prokaryotic and eukaryotic microbes

The paper identifies and characterizes a new conserved protein complex, CAGE, found in both prokaryotes and eukaryotes, revealing its structural features and evolutionary distribution.

Does AlphaFold2 model proteins' intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins

The paper tests if AlphaFold2 accurately models intracellular protein conformations using cross-linking mass spectrometry of endogenous ciliary proteins in Tetrahymena thermophila.

The protein organization of a red blood cell

This study defines the RBC proteome and interactome using mass spectrometry and machine learning, revealing key biological processes and structural models.

Simplified geometric representations of protein structures identify complementary interaction interfaces

The paper introduces a cuboid transformation of protein surfaces to predict interaction interfaces, achieving comparable accuracy to 3D docking methods while being faster and more tolerant to structural changes.