Author

Nicholas D. Sun

Mayo ClinicORCID 0000-0002-0735-7956Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adrian T. TingiD· 2 shared Allison R. CarriD· 2 shared Erica N. Krogman· 2 shared Matthew C. GuttormsoniD· 2 shared Akhilesh PandeyiD· 1 shared Daniel D. BilladeauiD· 1 shared Dusan BogunoviciD· 1 shared Haidong DongiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Adrian T. TingORCID

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2 papers

Recent·Most cited

TBK1 and IKKϵ protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism

Nicholas D. Sun, Allison R. Carr, Erica N. Krogman, Yogesh Kumar Chawla, Jun Zhong, Matthew C. Guttormson, Mark Chan, Michelle A. Hsu, Haidong Dong, Dusan Bogunovic, Akhilesh Pandey, Laura M. Rogers, Adrian T. Ting

This study shows that TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing by suppressing inflammatory apoptosis and NFκB-driven inflammation.

Science Signaling · Jul 7, 2026Peer-reviewedImmunology

T cells use TNF and IFNγ for paracrine killing with target discrimination programmed by pathogen-derived factors

Matthew C. Guttormson, Erica N. Krogman, Allison R. Carr, Skylar A. Rizzo, Josey Muske, Maia Ziaee, Nicholas R. Therrien, Nicholas D. Sun, Romina Ghale, Michael J. Medlyn, Daniel D. Billadeau, Larry R. Pease, Kathryn A. Knoop, Adrian T. Ting

The paper shows T cells can kill target cells via TNF and IFNγ in a paracrine, perforin-independent manner, with pathogen-derived factors enabling selective elimination of infected cells.

bioRxiv · Dec 25, 2025 · PreprintImmunology