Simone Mosole

Loss of ESE3/EHF is sufficient to promote cell plasticity, transformation and androgen-independent status in the early stage of prostate carcinogenesis.

This study shows that loss of EHF promotes cell plasticity, transformation, and androgen independence in early prostate cancer by disrupting lineage integrity and activating downstream pathways.

Tattoo ink induces inflammation in the draining lymph node and impairs the immune response against a COVID-19 vaccine

This study shows tattoo ink causes long-term inflammation in lymph nodes and reduces vaccine efficacy against COVID-19.

TRIM24 Degradation Counteracts Adaptation to Androgen Receptor Inhibition in Prostate Cancer

This study identifies TRIM24 as a target for preventing prostate cancer progression by degrading it to counteract AR inhibition adaptation and tumor relapse.

Generation of human cerebral organoids with a structured outer subventricular zone

This study generates human cerebral organoids with a structured outer subventricular zone by activating the STAT3 pathway with LIF, mimicking in vivo oRG development and enhancing neuronal maturation.