Benjamin T. Spike

Determination of Drug Sensitivity in Patient Derived Models of Breast Cancer by Multiparametric QPI

This paper demonstrates that multiparametric QPI can assess drug sensitivity in patient-derived breast cancer models, including cryopreserved samples, revealing cellular heterogeneity and resistance mechanisms.

HNF4α controls growth, identity and response to KRAS inhibition of invasive mucinous adenocarcinoma of the lung

Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin activation and FAK

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.

Factorization-based Imputation of Expression in Single-cell Transcriptomic Analysis (FIESTA) recovers Gene-Cell-State Relationships

FIESTA imputes missing values in scRNA-seq data using non-negative matrix factorization, improving gene-cell-state relationships and marker discovery.