Michelle C. Mendoza

This study shows ERK regulates nascent adhesion dynamics by promoting both assembly and disassembly, creating short-lived adhesions that support persistent cell migration.

This study reveals that ezrin activation involves spontaneous FERM-CTD dissociation triggered by PI(4,5)P2 binding, with phosphorylation stabilizing the open conformation.

This study identifies the mechanism by which ERK activates Rho and stress fibers through inhibition of Ezrin via phosphorylation of LOK, facilitating cell migration.

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.