Stewart W. Morris

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

This study identifies modifiable parent-of-origin effects on DNA methylation by analyzing genetic and environmental factors in a large cohort.

Identification of epigenome-wide DNA methylation differences between carriers of APOE ϵ4 and APOE ϵ2

This study identifies epigenome-wide DNA methylation differences between APOE ε4 and ε2 carriers in whole blood, implicating lipid-related genes.

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

This study links birth weight to adult health outcomes and DNA methylation differences, identifying a significant CpG site and associations with biological aging markers.

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

The paper identifies DNA methylation signatures associated with dementia risk factors in blood samples from individuals without Alzheimer's disease.

An epigenome-wide association study of sex-specific chronological ageing

This study identifies DNA methylation loci associated with age-by-sex interactions in a cohort of 2,586 individuals, finding most significant loci are X-linked and linked to disease-related genes.

A meta-analysis of genome-wide association studies of epigenetic age acceleration

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular health

The paper examines DNA methylation at the APOE gene in blood samples to assess its association with cholesterol, cognition, and risks of Alzheimer’s and cardiovascular disease.

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

This study identifies 29 differentially methylated sites associated with respiratory function and COPD, showing improved prediction of COPD risk when added to clinical models.

Assessment of Dried Blood Spots for DNA Methylation Profiling

The paper assesses DNA methylation profiles from dried blood spots (DBS) compared to EDTA tubes and finds they are highly correlated and suitable for epigenetic studies.

Bayesian reassessment of the epigenetic architecture of complex traits

This paper introduces a Bayesian method to estimate epigenetic associations with complex traits, finding that methylation data captures significant variance in BMI and smoking behavior.

Epigenetic signatures of starting and stopping smoking

The paper examines DNA methylation patterns in smokers and former smokers to determine how exposure duration and dose affect methylation changes and their reversal after cessation.

Epigenetic prediction of complex traits and death

The paper develops DNA methylation predictors for BMI, smoking, alcohol, and education, finding they explain some phenotypic variance and predict mortality for some traits.

DNA methylation age acceleration and risk factors for Alzheimer’s disease

The paper examines the relationship between DNA methylation age acceleration and Alzheimer’s disease risk factors, finding significant associations with BMI, cholesterol ratios, socioeconomic status, and smoking behavior.

Accelerated Epigenetic Ageing in Major Depressive Disorder

This study finds accelerated epigenetic ageing in major depressive disorder (MDD) cases compared to controls using the Horvath clock, partially mediated through BMI.