DAP12-deficient microglia adopt a TREM2-independent antigen-presenting state with a glial-to-neuronal cascade in Nasu-Hakola disease
Julio Leon, Satoshi Yoshinaga, Ikuko Koya, Grecia Palafox, Yoshinari Ando, Ken‐ichiro Kubo, Jonathan Moody, Masaki Takao, Piero Carninci, Jay W. Shin, Carlo Condello, Hideyuki Okano, Chung Chau Hon, Satoru Morimoto
The paper profiles NHD microglia and shows they adopt an antigen-presenting state without TREM2 dependence, triggering glial-to-neuronal changes.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience