Sumantra Chattarji

This study investigates the role of FMRP in oligodendrocyte maturation and myelination in human and rat models, finding shared defects in morphology and function.

This study shows that FMRP loss in microglia increases RAC1 signaling, leading to inflammation and neuronal hyperexcitability in FXS, which can be mitigated by RAC1 inhibition.

This paper investigates whether riluzole can reverse stress-induced delayed effects on the amygdala in rats, finding it reduces anxiety-like behavior and synaptic changes.

This study uses whole exome sequencing in families with multiple affected individuals to identify rare variants in genes associated with both Mendelian and complex neuropsychiatric syndromes.

This study determines the minimum sample size needed for multisite harmonization using structural brain MRI features and shows how sample size requirements increase with site variability.

The paper examines flight-freeze response imbalances in Nlgn3-/y rats, finding hyperexcitability in periaqueductal grey neurons linked to altered fear behaviors.

The paper analyzes whole exome sequencing data from individuals with severe mental illness to identify genes under positive selection and their biological functions.

The paper identifies a distinct temporal expression of GW182 in neurons during postnatal development and shows its role in regulating dendritic growth through actin dynamics and LIMK1 expression.

This study creates a rat model with SYNGAP enzymatic domain deletion, showing learning, social, and seizure deficits in heterozygous animals.

This study shows that chronic stress reduces pyramidal cell activity in mice but increases neuronal synchrony during sharp-wave ripples, potentially affecting hippocampal function.

The paper examines the relationship between adverse childhood experiences (ACEs) and the age of onset of psychiatric diagnoses in individuals from families with multiple affected members.

The paper shows that mGluR and NMDAR regulate protein synthesis and ATP consumption in cortical neurons through distinct kinetics and AMPK-eEF2 signaling.

This study shows that FMRP KO in mice leads to increased spiking variability in CA1 neurons of adult hippocampus but not juveniles, linked to elevated SK currents.

The paper shows that synGAP heterozygosity leads to increased TARP levels in the PSD of female rodents but not males, indicating a sex difference in PSD adaptation.

The paper shows that stress does not impair fear extinction when memories are formed before stress, despite increased amygdalar theta activity.