Author

Timothy Brendler-Spaeth

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:benchmarking· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Andrew J. WatersiD· 2 shared Andrew Roger BassettiD· 2 shared D. Adams· 2 shared Daniel P. GittermaniD· 2 shared Magdalena E StraußiD· 2 shared Abdel AyadiiD· 1 shared Adam CaulderiD· 1 shared Alasdair J. AllaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Andrew J. WatersORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SELECT-seq allows Pre-Sequencing Enrichment of SNP Edits in One-Pot Single-Cell Whole-Transcriptome Sequencing

Sho Iwama, Daniel P. Gitterman, Timothy Brendler-Spaeth, Andrew J. Waters, Holly Robertson, Magdalena E Strauß, D. Adams, Sarah E Cooper, Qianxin Wu, Andrew Roger Bassett

SELECT-seq enables rapid, scalable SNP-specific enrichment of single cells for genotype-phenotype analysis without cloning.

bioRxiv · Jul 8, 2026 · PreprintMolecular Biology

Saturation-seq integrates single-cell saturation genome editing and RNA-seq to quantify NFE2L2 (NRF2) variant effects

Magdalena E Strauß, Andrew J. Waters, Holly Roberston, Timothy Brendler-Spaeth, Aleksander M. Gontarczyk, Prashant Gupta, Shikha Kataria, Daniel P. Gitterman, Tumisang Ntereke, Leah Wells, Jamie Billington, Andrew Roger Bassett, Sarah Cooper, D. Adams

Saturation-seq combines genome editing and single-cell RNA-seq to quantify variant effects on NFE2L2, accurately distinguishing pathogenic from benign variants.

bioRxiv · Jul 4, 2026 · PreprintGenomics

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines

Hillary Elrick, Kevin A. Peterson, Brandon Willis, Denise Grant Lanza, Elif Fidan Acar, Edward J. Ryder, Lydia Teboul, Petr Kašpárek, Marie‐Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. M. Brown, Adam Caulder, Gemma F. Codner, , Valerie Laurin

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

Scientific Reports · Sep 30, 2024Peer-reviewedGenetics