Author

Tobias Cantz

Medizinische Hochschule HannoverORCID 0000-0002-1382-9577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Malte SgoddaiD· 2 shared Alex Bastianelli· 1 shared Amelie StalkeiD· 1 shared Annika BehrendtiD· 1 shared Björn Hartleben· 1 shared Carola DrögeiD· 1 shared Christian BäriD· 1 shared Christopher JahniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Malte SgoddaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Liver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency

Simon Alexander Krooss, Taihua Yang, Qinggong Yuan, Nora Drick, Malte Sgodda, Julia Held, Patrick Behrendt, Björn Hartleben, Rembert Koczulla, Xiaoying Ma, Ying Liu, Heiner Wedemeyer, Sabina M Janciauskiene, Nataliya Di Donato, Tobias Cantz, , Michael Ott

Liver biopsy after PI*ZZ gene correction therapy reveals efficient and accurate base editing.

medRxiv · Jun 9, 2026 · PreprintGenetic & Genomic Medicine

Nucleoside-Modified mRNA Encoding Alpha-Galactosidase A Reverses Fabry Disease Phenotypes in Human IPSC-Derived Cardiomyocytes

Malte Juchem, Sedef Ersoy, Lea Oehlsen, Jia Li Ye, Natalie Weber, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Christian Bär, Jeannine Hoepfner, Thomas Thum

This study shows that modGLA mRNA therapy reverses Fabry disease phenotypes in human iPSC-derived cardiomyocytes by restoring enzyme activity and normalizing molecular alterations.

bioRxiv · Dec 5, 2025 · PreprintMolecular Biology

Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotype

Annika Behrendt, Alex Bastianelli, Jan Stindt, Eva-Doreen Pfister, Malte Sgodda, Tobias Cantz, Sebastian Hook, Kathrin Grau, Stefanie Brands, Carola Dröge, Amelie Stalke, Michele Bonus, Sabine Franke, Ulrich Baumann, Verena Keitel, Holger Gohlke

This study identifies a missense variant in FXR that impairs its conformational transition to an active state, leading to reduced BSEP expression and a PFIC phenotype.

bioRxiv · Feb 8, 2024 · PreprintPhysiology