Hui Jiang

Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases

This paper introduces a new statistical method, RUNNER, to detect rare variants associated with complex diseases by comparing observed mutation burdens to predicted baseline values, showing improved power over existing methods.

Detection and characterization of copy number variants based on whole-genome sequencing by DNBSEQ platforms

This study evaluates CNV detection performance of DNBSEQ and Illumina platforms using WGS data from NA12878, showing DNBSEQ detects more CNVs with similar sensitivity and precision.

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

The paper introduces TRAP-seq to quantify CRISPR editing efficiency and uses it to design improved gRNAs for Cas9, ABE, and CBE with high accuracy and efficiency.

Generation and quality control of maternal plasma lipidomics data associated with preterm birth

The paper generates and validates an untargeted lipidomics dataset from maternal plasma samples associated with preterm birth, providing a resource for further research.