Xiangmin Xu

The paper shows that precise CA1 input topography shapes subicular spatial coding and network dynamics, while preserving single-cell tuning and impairing boundary vector coding and long-term stability.

This study examines age-related changes in the human hippocampus using multi-omics data, revealing cell-type loss and epigenetic reprogramming linked to cognitive decline.

The paper shows that proposed GPCR markers for adult dopamine neurons, like Nmur1 and Cckar, lack functional expression and challenge existing atlas assignments.

This paper presents a single-cell multiome atlas of the human basal ganglia, linking chromatin states and transcriptomes to cell-type identity and disease-associated variants.

The paper presents an integrated single-cell and epigenomic resource for exploring basal ganglia datasets across species, enabling multi-omics and comparative analysis.

This paper presents a chromosome-level genome assembly and annotation for the degu, improving contiguity, completeness, and gene annotation compared to previous assemblies.

The paper describes a multi-institutional program for collecting neurotypical human brains to support multiomic brain cell atlas studies, highlighting challenges and opportunities for donor recruitment.

This paper creates a high-resolution spatial transcriptomic atlas of the human basal ganglia, identifying 60 cell types and their spatial organization across multiple nuclei.

The paper shows that the L2/3 continuum in the mouse visual cortex develops through two phases: a genetically programmed initial phase and a visually experience-driven second phase.

This study shows that riluzole improves cognitive function and reduces neurodegeneration in mice after cranial radiation therapy by increasing BDNF levels and reducing neuroinflammation.

The paper identifies distinct functional roles of VTA dopamine subpopulations in reward association and motivation using electrophysiology and optogenetics in mice.

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.

The paper identifies separate neural populations in the subiculum that encode concave and convex environmental corners.

The paper introduces NeuronChat, a tool for inferring neuron-neuron communication networks from single-cell transcriptomics data, validated on human and mouse datasets and applied to autism spectrum disorder.

The paper identifies a novel stress-sensitive CRH GABA projection from the basolateral amygdala to the nucleus accumbens that contributes to reward behavior disruption following early-life adversity.

This study uses in vivo imaging to track microvascular recovery and remodeling after cortical injury, showing dynamic vascular growth and functional recovery over time.

The paper identifies non-canonical synaptic connections from ventral CA1 and subicular complex to CA3, expanding the traditional trisynaptic pathway in the hippocampal formation.

SCOUT improves neuronal tracking in longitudinal calcium imaging by reducing motion artifacts and false discoveries, enabling analysis of neural ensemble dynamics over 60 days.

This paper shows that subanesthetic ketamine reactivates adult cortical plasticity in mice, restoring vision from amblyopia through NRG1 downregulation in PV neurons.

This study investigates the effects of CNTNAP2 loss-of-function mutations in mice, finding reduced synaptic connectivity and altered oscillatory dynamics in the prefrontal cortex associated with autism-like behaviors.