Directed Evolution of Genetically Encoded LYTACs for Cell-Mediated Delivery
Jonathan Lee Yang, Sean A. Yamada‐Hunter, Louai Labanieh, Elena Sotillo, Joleen S. Cheah, David S. Roberts, Crystal Lee Mackall, Carolyn Ruth Bertozzi, Alice Y. Ting
The paper describes the development of genetically encodable LYTACs (GELYTACs) for targeted protein degradation using engineered T-cells, showing efficacy in secreting and delivering the therapeutics.
Proceedings of the National Academy of Sciences · Mar 21, 2024Peer-reviewedSynthetic Biology