Jeremy Copperman

Spatially coordinated RTK-ERK signaling dynamics shape osteosarcoma single-cell drug response in the lung microenvironment

This study identifies FGFR-ERK signaling as a driver of adaptive resistance in osteosarcoma lung metastases and shows that combinatorial RTK inhibition enhances MCL1 inhibitor efficacy.

A Compact, Standalone & Battery-Powered 3D Organoid-on-Chip System with Programmable Flow Control

The paper introduces a compact, battery-powered organoid-on-chip system with programmable flow control, validated for culturing pancreatic cancer organoids and showing enhanced proliferation and drug response.

Serial Imaging of Tumour and microEnvironment (SITE) platform for live-cell ex vivo modelling of primary and metastatic cancer dynamics

The paper introduces the SITE platform for live-cell ex vivo modeling of cancer and TME interactions, revealing tissue-specific dynamics and ERK signaling patterns in breast cancer.

Integrative Analysis of EGF, OSM, and TGFB Signaling Pathways Reveals Synergistic Mechanisms Driving Cell Motility Through CXCR2 Chemotactic Signaling and CREB Activation

This study investigates how combinations of EGF, OSM, and TGFB cytokines synergistically drive cell motility through CXCR2 chemotaxis and CREB activation in MCF10A cells.

Inferring single-cell dynamics of a molecular reporter from unlabeled live-cell light microscopy data analyzed with delay embedding

The paper uses delay embedding and VAE features to predict single-cell dynamics of a molecular reporter from unlabeled live-cell imaging data.

Morphodynamical cell state description via live-cell imaging trajectory embedding

This paper introduces a morphodynamical trajectory embedding method to analyze live-cell imaging data, revealing ligand-specific cell state transitions and improving trajectory modeling compared to snapshot-based analysis.