Author

Christel Claes

Leuven Stem Cell InstituteORCID 0000-0002-7765-0445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Adrian ListoniD· 1 shared Alessandra QuartaiD· 1 shared Amaia M. ArranziD· 1 shared Annerieke S. R. SierksmaiD· 1 shared Anton De SpiegeleeriD· 1 shared Bart De StrooperiD· 1 shared Bart M. J. De SpiegeleeriD· 1 shared Carlo Sala FrigerioiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Adrian ListonORCID

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2 papers

Recent·Most cited

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

Yorick Janssens, Nathan Debunne, Anton De Spiegeleer, Evelien Wynendaele, Marta Planas, Lídia Feliu, Alessandra Quarta, Christel Claes, Debby Van Dam, Peter Paul De Deyn, Peter Ponsaerts, Mathew M. Blurton-Jones, Bart M. J. De Spiegeleer

This study investigates the ability of the quorum sensing peptide PapRIV to activate BV-2 microglia and cross biological barriers, showing in vitro activation and in vivo presence.

Scientific Reports · May 21, 2021Peer-reviewedNeuroscience

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer's Disease

Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver T. Burton, Adrian Liston, Annerieke S. R. Sierksma, Yannick Fourne, Suresh Kumar Poovathingal, Amaia M. Arranz, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, , Bart De Strooper

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.

Nature Neuroscience · Oct 28, 2019Peer-reviewedNeuroscience