Author

Francesca Torelli

The Francis Crick InstituteORCID 0000-0002-2299-9543Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Organism:E. coli· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Moritz TreeckiD· 3 shared Simon W ButterworthiD· 3 shared Aaron CrowtheriD· 2 shared Eloise J. LockyeriD· 2 shared Jennifer L. RohniD· 2 shared Laia Pasquina-LemoncheiD· 2 shared Nicholas YueniD· 2 shared Ramón Garcia MasetiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

Moritz TreeckORCID

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5 papers

Recent·Most cited

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

Ramón Garcia Maset, Aaron Crowther, V. H. Chu, Davide De Grandi, Rizka Oktarianti Ainun Jariah, Jenny Yoon, Dalia Blumgart, Marloes Hoedek, Francesca Torelli, Nicholas Yuen, Benjamin O. Murray, Katie L. Holden, James M. Bancroft, Laia Pasquina-Lemonche, Sara N. H. Alghamd, , Jennifer L. Rohn

This study evaluates how the urinary microenvironment and fluid flow affect antibiotic and phage therapy against UPEC, showing that physiological conditions reduce treatment efficacy.

Nature Communications · Sep 4, 2026Peer-reviewedMicrobiology

Gut-relevant short-chain fatty acids modulate host-pathogen dynamics of uropathogenic Escherichia coli at the colonic epithelial interface

Nicholas Yuen, Ramón Garcia Maset, Wendy Wang, Manas Kubal, Zekun Chen, V. H. Chu, Ian J. White, Jinhui Gao, Francesca Torelli, Aaron Crowther, Laia Pasquina-Lemonche, Jennifer L. Rohn

This study investigates how gut-derived short-chain fatty acids affect uropathogenic Escherichia coli behavior and host-pathogen interactions at the colonic epithelial interface.

bioRxiv · Jan 19, 2026 · PreprintMicrobiology

In vivo CRISPR screens identify GRA12 as a transcendent secreted virulence factor across Toxoplasma gondii strains and mouse subspecies

Francesca Torelli, Simon Butterworth, Eloise J. Lockyer, Ana N. Matias, Franziska Hildebrandt, Ok‐Ryul Song, Jennifer E. Pearson-Farr, Moritz Treeck

The paper identifies GRA12 as a critical secreted virulence factor in Toxoplasma gondii that functions across different parasite strains and mouse species.

Nature Communications · Apr 16, 2025Peer-reviewedMicrobiology

Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

Francesca Torelli, D. Matos da Fonseca, Simon Butterworth, Joanna C. Young, Moritz Treeck

The paper shows that MYR1-deficient Toxoplasma gondii mutants are rescued by co-infection with wild-type parasites in mice, revealing a limitation of pooled in vivo CRISPR screens.

eLife · Dec 10, 2024Peer-reviewedMicrobiology

Mapping host-microbe transcriptional interactions by dual perturb-seq

Simon W Butterworth, Kristina Kordova, Sambamurthy Chandrasekaran, Kaitlin K. Thomas, Francesca Torelli, Eloise J. Lockyer, Amelia Edwards, Robert J. Goldstone, Anita A. Koshy, Moritz Treeck

This paper introduces dual perturb-seq, a method combining CRISPR screening and single-cell RNA-sequencing to identify host-microbe transcriptional interactions, revealing new effector proteins in Toxoplasma gondii.

bioRxiv · Apr 21, 2023 · PreprintMolecular Biology