Patrice Mollard

Population geometry reveals directed coupling and transient bistability in spontaneous pituitary secretion

The paper uses geometric analysis to show that spontaneous activity in pituitary cells generates self-sustained oscillators with transient bistability, linked to hormone secretion dynamics.

The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

This study identifies cholecystokinin (CCK) as the primary regulator of gonadotropin secretion in zebrafish, showing it controls ovarian development and FSH release.

Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty.

The paper shows that most gonadotrophs in adults originate from postnatal pituitary stem cells during minipuberty, while embryonic gonadotrophs are maintained, revealing a dual origin.

Nested calcium dynamics support daily cell unity and diversity in the suprachiasmatic nuclei of free-behaving mice

This study uses microendoscopic Ca2+ imaging to show that SCN neurons in vivo exhibit both fast Ca2+ spikes and slow baseline changes, revealing diverse activity patterns within a coordinated circadian network.

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

The paper shows that pituitary stem cells secrete WNT signals that promote the proliferation of neighboring progenitor cells.