Shlomo K. Melmed

This study investigates separase inhibition and cohesin protection in oocytes, finding that cohesin is not protected early in meiosis I and at metaphase II arrest, and that kinetochore individualization in meiosis I is required for cohesin cleavage in meiosis II.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.