Coordinated translational control of multiple immune checkpoints by the integrated stress response pathway in lung cancer
Shayna Elizabeth Thomas-Jardin, Shruthy Suresh, Ariana Arce, Nicole Novaresi, Qing Deng, Emily Stein, Lisa Thomas, Cheryl M. Lewis, Chul Woo Ahn, Bret M. Evers, Esra A. Akbay, Maria Esther Salvatierra, Wei Lü, Khaja B. Khan, Luisa M. Solis Soto, , Kathryn A. O’Donnell
The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.
Cancer Research · May 6, 2025Peer-reviewedCancer Biology