Yong Gu

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

Genome assembly and population genomic analysis of Aegilops caudata uncover a rich source for disease and insect pest resistance for wheat improvement

This paper presents a high-quality genome assembly of Aegilops caudata and identifies novel resistance genes for wheat pests and diseases through population genomic analysis.

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

The paper maps cell-type-specific eQTLs in IBD patients to identify effector genes and mechanisms linking genetic risk to disease.

TaWUS2D regulates the number of grains per spikelet by enhancing the number of fertile ovaries in Multi-Ovary Wheat

This study identifies TaWUS2D as a gene that increases grain number per spikelet by promoting fertile ovaries in wheat through genetic and genomic analyses.

A genome-scale single cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines

The paper presents a genome-scale CRISPRi perturbation map in human pluripotent stem cells using single-cell RNA sequencing to study trans gene regulation across diverse genetic backgrounds.

Origin and evolution of the bread wheat D genome

The paper analyzes the genetic composition and history of the bread wheat D genome using a pangenome of its donor species, revealing contributions from discrete subpopulations of Aegilops tauschii.

Identifying the best PCR enzyme for library amplification in NGS

The paper tests PCR enzymes for NGS library amplification, finding three that perform well for short reads and one that is best for long fragments.

The homoeologous genes for the Rec8-like meiotic cohesin in wheat: structure, function, and evolutionary implication

The paper identifies and analyzes Rec8-like homoeologous genes in wheat, revealing structural differences and differential expression patterns that suggest unique evolutionary dynamics of the B subgenome.