Dominik C. Kaczorowski

Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx

This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.

snPATHO-seq: unlocking the pathology archives

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.

High temporal resolution RNA-seq time course data reveals mammalian lncRNA activationmirrors neighbouring protein-coding genes

The paper analyzes high-resolution RNA-seq time course data to show lncRNAs are expressed synchronously with adjacent protein-coding genes, suggesting they may be by-products rather than regulators.

Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypes

The paper uses scRNA-seq and flow cytometry to identify novel immune and epithelial cell populations in preschool CF patients' bronchoalveolar lavage.

DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.

Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation

The paper investigates the subcellular relocalization of TRMT1 and TRMT1L during neuronal activation and identifies their role in RNA modification dynamics and neuronal plasticity.

Targeted, High-Resolution RNA Sequencing Of Non-Coding Genomic Regions Associated With Neuropsychiatric Functions

The paper identifies novel non-coding RNAs in human brain tissue associated with neuropsychiatric traits using targeted RNA capture and long-read sequencing.

High temporal resolution of gene expression dynamics in developing mouse embryonic stem cells

This study investigates gene expression dynamics in mouse embryonic stem cells at high temporal resolution, revealing new insights into transcriptional regulation and noncoding RNA roles.