Dongyin Guan

LiverHomo: An Integrated and Interactive Human Liver Single-Cell Atlas with Protein Interaction and Cell-Cell Communication Networks

LiverHomo integrates human liver scRNA-seq data with PPI and cell-cell communication networks to provide an interactive resource for exploring liver health and disease.

Dietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade

This study shows that dietary methionine restriction enhances T cell metabolism and improves anti-PD1 checkpoint blockade efficacy in immunocompetent tumor models.

The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis

This paper investigates 4-Methylumbelliferone's potential as a repurposed treatment for liver fibrosis, finding that it lacks efficacy at translatable doses and has an unclear mechanism.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Reversal of Obesity by Enhancing Slow-wave Sleep via a Prokineticin Receptor Neural Circuit

This study identifies a neural circuit linking appetite and sleep regulation, showing that targeting it with pterostilbene reduces obesity and improves sleep in diet-induced obese mice.