Ewan St. John Smith

The paper maps behavioral signatures of inflammatory pain and its relief in mice using computational tools and identifies that a common anti-inflammatory drug does not fully restore pre-injury behavior.

This study uses AAV-PHP.S to deliver chemogenetic receptors to knee-innervating DRG neurons, showing that inhibitory DREADDs reduce inflammation-induced pain in mice.

This study shows that TNF-α activated fibroblast-like synoviocytes sensitize knee neurons in vitro, contributing to inflammatory pain in arthritis.

The paper identifies a genetic variant in KCNG4 associated with increased labor pain by altering KV6.4 function in uterine nociceptors.

This study investigates acid and inflammatory sensitivity of colonic afferent nerves in naked mole-rats compared to mice, showing differential responses to acid and bradykinin.

This study shows galanin inhibits colonic afferent responses to mechanical and inflammatory stimuli via GalR1, with effects absent in inflamed tissue.

This study shows that acute knee inflammation in mice sensitizes sensory neurons and reduces digging behavior, mediated by TRPV1 receptor upregulation.

This study characterizes electrophysiological properties and MCH/HO neuronal distribution in the lateral hypothalamus of naked mole-rats, finding similarities to mice but distinct distribution patterns.

This study compares acid-induced cell death resistance between naked mole-rat and mouse cortical neurons, finding NMR neurons are more resistant due to smaller ASIC currents and reduced NaV activity.

This study shows that naked mole-rat ASIC3 forms non-functional homomers but functional heteromers with other ASIC subunits, explaining its insensitivity to acid.