Author

Matthew T. Klope

University of California, San FranciscoORCID 0000-0002-2801-6448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:plant (other)· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Adam R. RensloiD· 2 shared Adam S. FrostiD· 1 shared Aniliese DealiD· 1 shared Aswathy Vinod· 1 shared Avani Narayan· 1 shared Brian R. BlankiD· 1 shared Christopher P. ArthuriD· 1 shared D. John LeeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Adam R. RensloORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

Morgane Boone, Udit Dalwadi, Aniliese Deal, Ping Zhu, Tristan Ian Croll, Maya Yamazaki, Kimberly Prescott, Renato Minopoli, Isabella Biscocho, Junhua Wang, D. John Lee, Christopher P. Arthur, Thomas G. Laughlin, Hongyi Zhou, Matthew T. Klope, , Peter Walter

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

bioRxiv · Feb 7, 2026 · PreprintBiochemistry

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

Matthew T. Klope, Poulami Talukder, Brian R. Blank, Sevil Chelebieva, Jun Chen, Shaun D. Fontaine, Ryan L. Gonciarz, Priyadarshini Jaishankar, Grace J. Lee, Jennifer Legac, Vineet Mathur, Avani Narayan, Martin Okitwi, Stephen Orena, Nicholas S. Settineri, , Adam R. Renslo

The paper describes the discovery of new antimalarial trioxolanes effective against artemisinin-resistant parasites and their potential as development candidates for malaria treatment.

Science Advances · Aug 8, 2025Peer-reviewedPharmacology & Toxicology