Mark Carrington

An African trypanosome surface protein inhibits amplification of the complement system

The paper identifies a T. brucei surface protein that inhibits the complement system by blocking the C3bBb convertase.

A Trypanosoma brucei gambiense gene variant confers human serum resistance

The paper identifies a gene variant in Trypanosoma brucei gambiense that confers resistance to human serum, explaining how this subspecies evades trypanolytic factors.

Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

This study shows GPI-anchored receptors in Trypanosoma brucei are localized across the entire cell surface, not just the flagellar pocket, challenging previous assumptions about immune evasion.

An auxin-inducible degron system for trypanosomes

This paper describes the adaptation of an auxin-inducible degron system for trypanosomes by expressing a rice E3 ubiquitin ligase to enable specific protein degradation.

Insights from aquaporin structures into drug-resistant sleeping sickness

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors

This study shows that Trypanosoma brucei lacks a functional EJC and NMD pathway due to intron loss and gene redundancy.

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.