Helder André

MITF is essential for autophagy in the retinal pigment epithelium

This study shows that MITF regulates autophagy in RPE cells, with reduced MITF causing autophagy defects and lysosomal dysfunction linked to retinal degeneration.

Anatomy of the complete mouse eye vasculature indevelopment and pathology explored by light-sheet fluorescence microscopy

The paper uses light-sheet fluorescence microscopy to visualize and analyze the complete vasculature of mouse eyes across development and disease.

Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.

When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma

The paper shows that microglia activation occurs in the contralateral eye of unilateral glaucoma models, suggesting the contralateral eye may not be a valid control.