Staci A. Weaver

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis

This study shows that miR-146a-5p overexpression in beta cells under inflammatory stress causes mitochondrial dysfunction and apoptosis, while its inhibition reverses these effects.

Cigarette Smoke Exposure Impairs β-Cell Function Through Activation of Oxidative Stress and Ceramide Accumulation

This study shows cigarette smoke exposure impairs β-cell function through oxidative stress and ceramide accumulation, with effects persisting after smoking cessation.