Author

Stéphane Demine

Indiana Biosciences Research InstituteORCID 0000-0002-7254-2269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alessandra Kupper CardozoiD· 1 shared Alexandra Coomans de BrachèneiD· 1 shared Andrés Balaguer RomániD· 1 shared Ângela Castela· 1 shared Ao LiiD· 1 shared Arnaud ZaldumbideiD· 1 shared Bruno Ramos‐MolinaiD· 1 shared C. E. BussiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

Alessandra Kupper CardozoORCID

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2 papers

Recent·Most cited

PTPRF is a stress responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells

Mayank Bansal, Wadsen St‐Pierre‐Wijckmans, Javier Negueruela, C. E. Buss, Francisco Ribeiro-Costa, Ao Li, Tiffany Lai, Vishnu M. Nair, Valerie Vandenbempt, Michela Lisjak, Israel Pérez-Chávez, Gayane Hovhannisyan, Daria Ezeriņa, Mehmet Bostancıklıoğlu, Stéphane Demine, , Esteban N. Gurzov

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

bioRxiv · Sep 7, 2026 · PreprintPhysiology

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

Farooq Syed, Olivia Ballew, Chih‐Chun Lee, Jyoti Rana, Preethi Krishnan, Ângela Castela, Staci A. Weaver, Namratha Shivani Chalasani, Sofia Thomaidou, Stéphane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Inês Alvelos, Eugenia Martin Vázquez, Lorella Marselli, , Carmella Evans‐Molina

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

EBioMedicine · May 6, 2025Peer-reviewedPhysiology