William J. Faller

Mitochondrial damage triggers therapy-induced senescence

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

NAC-mediated ribosome localization regulates cell fate and metabolism in intestinal stem cells

RNA dicing regulates the expression of an oncogenic JAK1 isoform

The paper shows RNA dicing produces an oncogenic JAK1 isoform, affecting cell proliferation and tumorigenesis, and highlights its therapeutic implications.

Ribo-ODDR: Ribo-seq focused Oligo Design pipeline for experiment-specific Depletion of Ribosomal RNAs

Ribo-ODDR improves rRNA depletion in Ribo-seq by designing experiment-specific oligos, increasing sequencing depth and information yield.