Author

Carole Shum

King's College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 3 Genetic & Genomic Medicine· 2

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Organism:human· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:variant calling· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Deepak P. SrivastavaiD· 3 shared Jack PriceiD· 3 shared Lucia Dutan PolitiD· 3 shared Brett TrostiD· 2 shared Evdokia A. AnagnostouiD· 2 shared Grainne Mary McAlonaniD· 2 shared Jeffrey R. MacDonaldiD· 2 shared Jennifer Howe· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Deepak P. SrivastavaORCID

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Author profile →

5 papers

Recent·Most cited

Genetic variants in DDX53 contribute to Autism Spectrum Disorder associated with the Xp22.11 locus

Marcello Scala, Clarrisa A. Bradley, Jennifer Howe, Brett Trost, Nelson Bautista Salazar, Carole Shum, Marla Mendes de Aquino, Miriam S. Reuter, Evdokia A. Anagnostou, Jeffrey R. MacDonald, Sangyoon Y. Ko, Paul W. Frankland, Jessica Charlebois, Mayada Elsabbagh, Leslie Granger, , Stephen W. Scherer

The paper identifies DDX53 genetic variants in individuals with ASD, showing a link between DDX53 and ASD, and highlights implications for genetic testing and mouse modeling.

The American Journal of Human Genetics · Dec 19, 2024Peer-reviewedGenetic & Genomic Medicine

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells

Anjali Bhat, Haritz Irizar, Amalie C. M. Couch, Pooja Raval, Rodrigo R. R. Duarte, Lucia Dutan Polit, Bjørn Hanger, Timothy R. Powell, P. J. Michael Deans, Carole Shum, Roland Nagy, Grainne Mary McAlonan, Conrad Osamede Iyegbe, Jack Price, Elvira Bramon, , Deepak P. Srivastava

The paper shows that schizophrenia hiPSC-derived NPCs have a reduced transcriptional response to IFN-gamma compared to controls, with implications for synaptic development and mitochondrial genes.

Brain Behavior and Immunity · Jun 15, 2022Peer-reviewedNeuroscience

Genomic architecture of autism spectrum disorder from comprehensive whole-genome sequence annotation

Brett Trost, Bhooma Thiruvahindrapuram, Ada J. S. Chan, Worrawat Engchuan, Edward J. Higginbotham, Jennifer Howe, Livia Oliveira Loureiro, Miriam S. Reuter, Delnaz Roshandel, Joe Whitney, Mehdi Zarrei, Matthew Bookman, Cherith Somerville, Rulan Shaath, Mona Abdi, , Evdokia A. Anagnostou

This study identifies 135 ASD-associated protein-coding genes using whole-genome sequencing data from 11,312 individuals and exome sequencing from over 18,000 trios, with a false discovery rate of 80%.

medRxiv · May 5, 2022 · PreprintGenetic & Genomic Medicine

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals

Dwaipayan Adhya, Vivek Swarup, Roland Nagy, Lucia Dutan Polit, Carole Shum, Eva P. Valencia-Alarcón, Kamila Maria Jozwik, María Andreina Méndez, Jamie Horder, Eva Loth, Paulina Nowosiad, Irene Lee, David Skuse, Frances A. Flinter, Declan Murphy, , Simon Baron‐Cohen

This study uses iPSCs from autistic individuals to identify early neurodevelopmental differences during cortical and midbrain differentiation.

Biological Psychiatry · Jun 23, 2020Peer-reviewedNeuroscience

Δ9-tetrahydrocannabinol negatively regulates neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons.

Carole Shum, Lucia Dutan Polit, Emily Annuario, Katherine M. Warre-Cornish, Samuel E. Taylor, Ruth D. Taylor, Laura C. Andreae, Noel J. Buckley, Jack Price, Sagnik Bhattacharyya, Deepak P. Srivastava

This study shows that Δ9-THC inhibits neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons via CB1R activation.

bioRxiv · Dec 20, 2018 · PreprintNeuroscience