Lucy F. Stead

The immune and genetic heterogeneity of Hepatocellular Carcinoma, with a focus on multifocal disease

This study examines genetic and immune heterogeneity in HCC, finding significant discordance in genetic and immune profiles between multifocal tumours.

Sexual Dimorphism of Cancer-Associated Fibroblasts Governs Matrix and Vascular Organisation in Breast Cancer

This study shows that male and female cancer-associated fibroblasts in breast cancer have distinct transcriptional programs and functional behaviors affecting matrix and vascular organization.

Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment

This study uses imaging mass cytometry to analyze changes in glioblastoma tumor microenvironment before and after treatment, finding increased normal brain cells and altered cellular interactions post-treatment.

GBMPurity: A Machine Learning Tool for Estimating Glioblastoma Tumour Purity from Bulk RNA-seq Data

GBMPurity is a deep learning tool that estimates glioblastoma tumour purity from bulk RNA-seq data, outperforming existing methods and revealing subtype-specific purity patterns.

Single Cell Track and Trace: live cell labelling and temporal transcriptomics via nanobiopsy.

This paper introduces a method to profile the transcriptome of live cells over time, showing treatment induces transcriptionally stable cells in glioblastoma.

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.