Sandra L. Grimm

Lifecourse sex-specific molecular response to early-life exposures of toxic substances

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis

This study identifies sumf2 as a key regulator of convergence and extension morphogenesis timing in zebrafish by modulating sulfatase activity and heparan sulfate sulfation.

Cell type-independent timekeeping gene modules enable embryonic stage prediction in zebrafish

The paper identifies timekeeping gene modules in zebrafish embryos that predict developmental stages across different tissues and species.

Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor

This study identifies non-consensus XRE (NC-XRE) motifs as functional AHR binding sites in mouse liver, showing their role in regulating gene expression through direct transcriptional control.

Comprehensive Transcriptomic and Epigenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression Trajectories

The paper shows early-life toxicant exposure reprograms epigenomic aging, altering gene expression in liver cells and disease risk in adulthood.

Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis

The paper shows that temporal BMP/Nodal signaling ratios drive tissue-specific convergence and extension movements during zebrafish gastrulation.

Nerve injury inhibits Oprd1 and Cnr1 transcription through REST in primary sensory neurons

This study shows that nerve injury represses Oprd1 and Cnr1 transcription via REST in primary sensory neurons, suggesting REST as a therapeutic target for neuropathic pain.

Genomic and Proteomic Analysis of Patients with Reoccurring Discrete Subaortic Stenosis

This study analyzes genomic and proteomic differences between recurrent and non-recurrent discrete subaortic stenosis patients to identify predictive markers for reoccurrence.

MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: further evidence for opioid-induced neurovascular alterations

The paper analyzes miRNA-mRNA networks in postmortem brain and blood samples from opioid use disorder patients, identifying dysregulated pathways and potential therapeutic targets.

Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

The paper identifies CoRSIVs with strong genetic control of methylation and links them to transposable elements and disease.