The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
Jonathan Richard, Michael W. Grunst, Ling Niu, Marco Aurelio Díaz-Salinas, Li Zhu, William David Tolbert, Lorie Marchitto, Fei Zhou, Catherine Bourassa, H.O. Kim, Sri Lakshmi Tejaswi Boodapati, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Mehdi Benlarbi, , Andrés Finzi
This study shows that the CD4 mimetic CJF-III-288 enables anti-CoRBS antibodies to mediate ADCC by stabilizing an asymmetric open Env conformation.
Nature Communications · Dec 1, 2025Peer-reviewedMicrobiology