Author

Pradeep Devappa Uchil

Yale UniversityORCID 0000-0002-7236-858XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Walther MothesiD· 2 shared Aaron M. RingiD· 1 shared Akiko IwasakiiD· 1 shared Aleksandra SynowieciD· 1 shared Alexandra SchäferiD· 1 shared Alicen Burns SpauldingiD· 1 shared Arthur S. KimiD· 1 shared Bárbara MülleriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

Walther MothesORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation

James C. V. Stacey, Dominik Hrebík, Elizabeth Nand, Snehith Dyavari Shetty, Kun Qu, Marius Boicu, Maria Anders‐Össwein, Pradeep Devappa Uchil, Robert A. Dick, Walther Mothes, Hans‐Georg Kräusslich, Bárbara Müller, John A. G. Briggs

This study identifies SP2 as a trigger for HIV-1 MA lattice maturation, showing it binds MA to induce structural changes and enhance viral infectivity.

Nature · Feb 26, 2025Peer-reviewedMicrobiology

HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors

Mia Madel Alfajaro, Emma L. Keeler, Ning Li, Nicholas Catanzaro, I‐Ting Teng, Zhe Zhao, Michael W. Grunst, Boyd L. Yount, Alexandra Schäfer, Danyi Wang, Arthur S. Kim, Aleksandra Synowiec, Mario A. Peña-Hernández, Ridwan Arinola, Ramandeep Kaur, , Craig B. Wilen

This study identifies bat and mink ACE2 as receptors for HKU5 merbecovirus, revealing distinct receptor interactions and highlighting mustelids as potential intermediate hosts.

bioRxiv · Feb 12, 2025 · PreprintMicrobiology

Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues

Mark S. Ladinsky, Li Zhu, Irfan Ullah, Pradeep Devappa Uchil, Priti Kumar, Michael S. Kay, Pamela J. Björkman

The paper uses electron tomography to visualize HIV-1 virions trapped by fusion inhibitors in infected tissues, revealing pre-hairpin intermediates linked to host cells.

Journal of Virology · Oct 30, 2024Peer-reviewedMicrobiology