Mikala Egeblad

Continuous tissue fields organize immune composition in pancreatic cancer

This study identifies continuous spatial organization of immune composition and tumor identity in pancreatic cancer using spatial transcriptomics and single-cell imaging.

FAK Inhibition Remodels the Metastatic ECM and Restores CD8+ T Cell Trafficking and Immunosurveillance

This paper shows that FAK inhibition remodels the metastatic ECM, enhancing CD8+ T cell infiltration and immunosurveillance in breast cancer.

Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

Host response during unresolved urinary tract infection alters mammary tissue homeostasis through collagen deposition and TIMP1

This study shows that unresolved urinary tract infection leads to mammary tissue changes via collagen deposition and TIMP1, mediated by systemic host response.