Author

Stéphane Dalle

Centre National de la Recherche ScientifiqueORCID 0000-0002-3423-4548Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:ATAC-seq· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Julie CarameliD· 4 shared Maxime GrimontiD· 4 shared Anaïs EberhardtiD· 3 shared Bertrand DuboisiD· 2 shared Christophe CauxiD· 2 shared Félix BoiviniD· 2 shared Félix PhamiD· 2 shared Jenny Valladeau‐GuilemondiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Julie CaramelORCID

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4 papers

Recent·Most cited

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanoma

Félix Pham, Marion Dufeu, Valentin Benboubker, Maxime Grimont, Amelie LHORISSON, Justine Berthet, Marie Donzel, Raphaël Schneider, Laurie Tonon, Anne‐Claire Doffin, Félix Boivin, Simon Durand, Bertrand Dubois, Jonathan Lopez, Christophe Caux, , Julie Caramel

This study maps spatial tumour-immune interactions in melanoma and identifies how their organization affects anti-PD1 therapy efficacy.

bioRxiv · Jul 7, 2025 · PreprintCancer Biology

The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

Simon Durand, Félix Boivin, Roxane M. Pommier, Laetitia Barbollat‐Boutrand, Maxime Grimont, Félix Pham, Marion Dufeu, Eric Cumunel, Raphaël Schneider, Anthony Ferrari, Anaïs Eberhardt, Stéphane Dalle, Julie Caramel

This study identifies TRIM24 as an epigenetic regulator that promotes melanoma cell dedifferentiation and treatment resistance, with potential as a druggable target.

bioRxiv · May 20, 2025 · PreprintCancer Biology

BMP-dependent oligoclonal cancer attractor state precedes neural crest fate in melanoma initiation

Alicia M. McConnell, Maggie H. Chassé, Haley R. Noonan, Jeffrey K. Mito, Julia Barbano, Erika Weiskopf, Irene F. Gosselink, Song P. Yang, Kyle D. Drake, Chloé S. Baron, Elise Layne, Meera Prasad, Phammela Abarzua, Maxime Grimont, Yung-Ching Kao, , Leonard Ira Zon

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

bioRxiv · Oct 22, 2024 · PreprintCancer Biology

Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma

Elisa Gobbini, Margaux Hubert, Anne-Claire Doffin, Anais Eberhardt, Leo Hermet, Danlin Li, Pierre Duplouye, Sarah Barrin, Justine Berthet, Valentin Benboubker, Maxime Grimont, Candice Sakref, Jimmy Perrot, Garance Tondeur, Olivier Harou, , Jenny Valladeau-Guilemond

This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.

bioRxiv · Feb 6, 2024 · PreprintCancer Biology