Lillian L. Siu

Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial

This study evaluates the ecological fidelity of HMA mice in replicating human microbiome responses to a microbial consortium, finding they are more similar to other mice than their human donors.

The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression.

This study investigates the dual role of EphA4 in T regulatory cells and tumor-associated macrophages during HNSCC progression, showing pro-tumoral and anti-tumoral effects respectively.

CanDIG: Secure Federated Genomic Queries and Analyses Across Jurisdictions

CanDIG enables secure, federated genomic and health data analysis across jurisdictions while maintaining data locality and privacy.

Genome analysis and data sharing informs timing of molecular events in pancreatic neuroendocrine tumour

The paper analyzes genomic data from pancreatic neuroendocrine tumors to identify a widespread copy neutral loss-of-heterozygosity pattern linked to tumor progression and potential therapeutic targets.